In silico analysis of the functional non-synonymous single nucleotide polymorphisms in the human CYP27B1 gene

In silico analysis of the functional non-synonymous single nucleotide polymorphisms in the human CYP27B1 gene

CYP27B1 gene codes for 25-hydroxyvitamin D3 1-α-hydroxylase, an enzyme that catalyses the activation of vitamin D to the 1-α, 25 dihydroxyvitamin D3. The activity of this enzyme is altered by non-synonymous single nucleotide polymorphisms (nsSNPs) located within its gene. Such alterations consequently affect the synthesis of the active form of the hormone, 1-α, 25 dihydroxyvitamin D3,...
 
Published at Egyptian Journal of Medical Human Genetics
Published in 2018
 
 
visit (https://www.sciencedirect.com/science/article/pii/S1110863018300259)
 
 
Solomon O Rotimi, Olamide Peter, Oluwayomi Oguntade, Oluwakemi A Rotimi
Rotimi Oluwakemi
 
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