Acute aflatoxin B1 – Induced hepatotoxicity alters gene expression and disrupts lipid and lipoprotein metabolism in rats

Acute aflatoxin B1 – Induced hepatotoxicity alters gene expression and disrupts lipid and lipoprotein metabolism in rats

In this study, alterations in lipid metabolism associated with acute aflatoxin B1 (AFB1) induced hepatotoxicity and gene expression changes underlying these effects were investigated. Rats were orally administered three doses (0.25 mg/kg, 0.5 mg/kg and 1.0 mg/kg) of AFB1 for seven days; after which blood was collected and liver excised. Lipid profiles of plasma and liver were determined...
 
Published at Toxicology reports
Volume 4
Pages 408-414
Published in 2017
 
 
visit (https://www.sciencedirect.com/science/article/pii/S2214750017300495)
 
 
Oluwakemi Anuoluwapo Rotimi, Solomon Oladapo Rotimi, Chibueze Uchechukwu Duru, Ogheneworo Joel Ebebeinwe, Anthonia Obhio Abiodun, Boluwaji Oluwamayowa Oyeniyi, Francis Adedayo Faduyile
Rotimi Oluwakemi
 
Other publications by this author (view profile)
 
 
Persistence of acidosis in alloxan-induced diabetic rats treated with the juice of Asystasia gangetica leaves
 
In silico analysis of compounds characterized from ethanolic extract of Cucurbita pepo with NF-κB-inhibitory potential
 
Effects of fibre-enriched diets on tissue lipid profiles of MSG obese rats
 
Effects of Quercetin and α-Lipoic Acid on Acetylcholine Esterase and Paraoxonase Activities in α-Cypermethrin Treated Rats
 
Effects of Quercetin and α-Lipoic Acid on α-Cypermethrin-Induced Oxidative Stress in Rats
 
Gas chromatography-mass spectrometry identification of anticancer phytochemicals in Aframomum danielli
 
Investigation of Angiostensin-converting enzyme inhibitory potential and allergenicity of Sesamum indicum Linn seed proteins by an in silico approach
 
Coexistence of aflatoxicosis with protein malnutrition worsens hepatic oxidative damage in rats
 
Hesperidin prevents lipopolysaccharide-induced endotoxicity in rats
 
Oxidative stress in extrahepatic tissues of rats co-exposed to aflatoxin B1 and low protein diet
 
Naringin enhances reverse cholesterol transport in high fat/low streptozocin induced diabetic rats
 
Effects of naringin on apoptosis and oxidative stress in type 2 diabetic rats
 
In silico analysis of the functional non-synonymous single nucleotide polymorphisms in the human CYP27B1 gene
 
Stevioside modulates oxidative damage in the liver and kidney of high fat/low streptozocin diabetic rats
 
Alterations of Genes Involved in Apoptosis and Epigenetic Modulation Associated with Gatifloxacin-Induced Oxidative Stress in Rat Liver
 
Time-Course Effects of Acute Aflatoxin B1 Exposure on Hepatic Mitochondrial Lipids and Oxidative Stress in Rats