The Effect of Heme-linked Ionizable Groups on Cyanide Binding to Methemoglobin

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The pH dependence of the kinetics of the binding of cyanide ion to methemoglobins A and S and to guinea pig and pigeon methemoglobins appears to be not directly correlated with the net charges on the proteins. The kinetics can, howeverb, e adequately explained in terms of three sets of heme-linked ionizable groups with pK, ranging between 4.9 and 5.3, pK, between 6.2 and 7.9, and pK3 between...

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FJ Vega-Catalan, OJ Odeyemi & KO Okonjo

Okonjo Kehinde » Born 1942. Educated King's College, Lagos (1957-63). BSc, PhD (University of Ibadan). Retired Professor of Chemistry, University of Ibadan. Currently Professor of Chemistry, Covenant University. Current research interests: Kinetics and thermodynamics of reactions of reaction of Ellman's reagent with hemoglobin sulphydryl groups. Publications in such high impact journals as the Journal of... view full profile

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