Facile synthesis and characterization of substituted pyrimidin-2(1H)-ones and their chalcone precursors.

Facile synthesis and characterization of substituted pyrimidin-2(1H)-ones and their chalcone precursors.

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A new and efficient method has been developed for the quantitative transformation of chalcones to pyrimidine frame work via solid support catalysis. Silica supported sulfuric acid (SSA) efficiently catalyzes the reaction of α,β-unsaturated carbonyl, chalcones (1-10) with urea to afford substituted pyrimidin-2(1H)-ones (11-20) in good to excellent yield. The interesting behaviour of SSA lies...
 
Published at Pakistan Journal of Scientific and Industrial Research
Volume 54
Issue 2
Pages 59-67
Published in 2011
 
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Ajani, O.O., Ituen, R.I. and Falomo, A.
AJANI OLAYINKA OYEWALE » Prof. Olayinka Oyewale AJANI is an expeditious chemist who has distinguished himself both as a seasoned industrialist and a prolific researcher in the academic world especially in the area of Organic Synthesis and Medicinal Chemistry. He obtained his Master’s degree in Chemistry in 2006 from Obafemi Awolowo University, Ile-ife, Osun State, Nigeria. In 2012, Ajani O.O. obtained his Doctoral... view full profile
AJANI OLAYINKA OYEWALE
 
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